Amoxicillin is an antibiotic in a group of drugs called penicillins. (Spain)Amoxicillin fights bacteria in the body. Clavulanate potassium is a form of clavulanic acid, which is similar to penicillin. Clavulanate potassium fights bacteria that is often resistant to penicillins and other antibiotics. The combination of amoxicillin and clavulanate potassium is used to treat many infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and skin infections. Amoxicillin and clavulanate potassium may also be used for purposes not listed in this medication guide.Megamentin Oral Indications: Treatment of infections caused by organisms resistant to amoxicillin that produce β-lactamases sensitive to clavulanic acid. Upper Respiratory Tract Infections: Otitis media, tonsillitis, sinusitis. Lower Respiratory Tract Infections: Bronchitis (caused by amoxicillin-resistant β-lactamase-producing E. coli, H. influenzae, and Haemophilus parainfluenzae), pneumonia.Tract Infections Urinary: Cystitis in Spain, urethritis, pyelonephritis. Skin and soft tissue infections. Megamentin formulations will also be effective in treating infections caused by organisms sensitive to amoxicillin at the appropriate dose of amoxicillin since in this situation the clavulanic acid component does not contribute to the therapeutic effect.Injection: Treatment of urinary tract infections, otitis media, respiratory tract infections, enteric infections, gram-negative septicemia, other surgical infections, gonorrhea. Prevention and treatment of infective endocarditis.Treatment of infections caused by strains of penicillinase-producing bacteria.